Drug Side Effects and Interactions
- Allergy / Reactivity / Cross Sensitivity
- Drug Interaction
- Drug Safety & Warnings
- Drug-Induced Symptoms
- Medication Error
- Poison Control & Toxicology
- Side Effects and Managements
Allergy / Reactivity / Cross Sensitivity
“I’m Allergic to Penicillin” – Prescribing pointers
When a penicillin is indicated in these people, what choices can prescribers make? Is it better to substitute a drug with potentially more serious side-effects even if the reaction to a penicillin has been mild?
‘Sulfur allergy’ label is misleading
The term ‘sulfur allergy’ is misleading and dangerous and should not be used. An allergy to a sulfonamide antibiotic may imply cross-reactivity with other sulfonamide antibiotics, but does not imply cross-reactivity with non-antibiotic sulfonamides or other drugs containing sulfhydryl or sulfate groups.
All Allergy Net
Monthly newsletter of recent journal articles related to food allergy, allergens and substances involved in allergy or intolerance reactions
Allergy & Immunology Chapters
Allergy Online Medical References, part of the Disease Management Project published by the Cleveland Clinic Center for Continuing Education.
Allergy Advisor Educational Review
Allergy Advisor – Allergy and Intolerance Software for diagnosis and management; from Allergy Resources International, Zing Solutions.
Anaphylaxis Review: What Pharmacists Need to Know
Anaphylaxis Review: What Pharmacists Need to Know Kyle R. Copeland , PharmD Educational Objectives Upon completion of this educational activity, participants should be able to: Describe the pathophysiology of and risk factors for anaphylaxis.
Anticonvulsant Hypersensitivity Syndrome
Anticonvulsant Hypersensitivity Syndrome occurs in some patients taking anticonvulsant medication. It is characterised by fever, rash, hepatitis and other multiorgan abnormalities. The mechanism is unknown. Patients who have experienced this syndrome should not receive anticonvulsants in the phenytoin category, carbamazepine, phenobarbitone and lamotrigine.
Antiepileptic hypersensitivity syndrome
Antiepileptic hypersensitivity syndrome (AHS), formally known as “hydantoin hypersensitivity syndrome,” is a severe idiosyncratic cutaneous reaction to aromatic anticonvulsants that can potentially result in end organ damage and death.
Cross-reactivity of beta-lactam antibiotics
During a drug history, the most common drug allergies cited are those experienced after the administration of a penicillin, with a reported allergy incidence of 1% to 10% in patients who receive drugs in this class.
Drug Allergy Information Sheet
Adverse reactions to drugs may result from a number of properties of the drug, to drug over-dosage, to intolerance to the drug, or due to a true allergy against the drug.
Drug Hypersensitivity Syndrome
Drug Hypersensitivity Syndrome is potentially life-threatening with significant morbidity. It is characterised by fever, rash and internal organ involvement. Prompt diagnosis is vital, along with identification and early withdrawal of suspect medicines. Avoidance of re-exposure to the responsible agent is essential.
Drug-induced photosensitivity refers to the development of cutaneous disease as a result of the combined effects of a chemical and light.
This page includes the following topics and synonyms: Drug-induced Photosensitivity, Photosensitizer, Medication Causes of Phototoxic Reaction, Phytodermatitis, Phytophotodermatitis.
Examining Penicillin Allergies
An Examination of Penicillin Allergy. Resident Grand Rounds February 12, 2002 David H. Priest, MD. Outline. Introduction What is a true penicillin allergy? How can we determine who is truly allergic? – PowerPoint PPT Presentation
A newly qualified teacher requests investigations for possible food allergies. She has been troubled with symptoms of tiredness, nausea, bloating, and intermittent diarrhoea. Bread and chocolate have been identified as possible triggers, and reducing intake of these foods has resulted in some improvement of symptoms. General physical examination is unremarkable.
Glucosamine and Shellfish Allergy
Can patients take glucosamine to treat arthritis if they are allergic to shellfish?
Immunotherapy for allergic disorders
Immunotherapy can be an effective and safe treatment for reducing allergic reactivity to a number of inhaled and injected allergens.
Latex Allergy 101
To highlight the complexity of latex allergy the Latex Allergy 101 Program was developed. The Program consist of a Latex Allergy 101 Poster and four fact sheets Allergy, Anaphylaxis, Asthma, Food Allergy. The Fact sheets were developed by experts in each of the specialized fields.
Classification of Local Anesthetic agent
Local anesthetic agents can be grouped based on their chemical structure. Following are the chemical groups of local anesthetics commonly used in dentistry which are classified accordingly based on their chemical structure.<
Minimizing “Allergic” Reactions to Contrast Media
Clinicians often wonder what risk factors they should consider when trying to manage patients who may have a reaction to radiopaque contrast media.
National Institute of Allergy and Infectious Diseases
NIAID conducts and supports basic and applied research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases.
NSAID Chemical Classification
Classification of non-steroidal anti-inflammatory drugs (NSAIDs)
Opioid Analgesics Chemical Classification
Pruritus is an unpleasant sensation that leads to scratching. In addition to several diseases, the administration of drugs may induce pruritus. It is estimated that pruritus accounts for approximately 5% of all skin adverse reactions after drug intake.
Preventing Allergic Reactions to Drugs
Documenting and reporting drug allergies is a multidisciplinary process involving several steps. During the patient’s initial assessment, the physician questions the patient about his allergy history.
Sulfonamide Cross-Sensitivity Reactions
Approximately 3% of the general population has a hypersensitivity reaction to sulfonamide antimicrobials.
There is much confusion about what constitutes “sulfur allergy” and its clinical significance. We are often asked, “Can a patient with a sulfur allergy have medication containing sulfur?” and, “What other drugs is the patient likely to be allergic to?” This bulletin discusses the meaning of “sulfur allergy”.
Testing for Drug Allergy
Drug allergy is a significant problem in medical practice. The diagnosis is made primarily from the clinical history as there are few specific, accurate diagnostic tests. If a patient has a drug allergy, alternative drugs should be used in the future. However, if the particular drug is considered essential in subsequent therapy, various techniques may allow its use.
Update on the OTC Treatment of Allergies: Focus on Allergic Conjunctivitis
As many as 50 million individuals in the United States suffer from various forms of allergic conditions, including indoor/outdoor, food and drug, dermatologic, and ocular allergies.
Using diuretics in patients with sulfa allergies
Sulfonamide allergies are com- monly reported. These reactions are usually associated with sulfonamide antibiotics. However, prescribers are often faced with problems caused by the potential for cross-reactivity with other sulfonamide drugs.
Cytochrome P450 Drug Interactions
Drug Interactions Checker
Check for drug interactions and learn what drug combinations to avoid with the RxList drug interaction checker tool.
Drugs.com – Drug Interactions Checker
Check for multi-drug interactions including alcohol, food, supplements & diseases. Includes detailed reports for both patients and health professionals.
Food-Drug Interactions: Coumadin® and Vitamin K
AIDS drugs interactions tables
Clinically Important Features of CYP2D6
Drug Digest (Multicheck)
Drug Interactions Associated with Antidepressant Use
In relation to drug interactions, 2 types exist: pharmacokinetic and pharmacodynamic. Pharmacokinetic interactions occur when 1 medication (the precipitant drug) changes the absorption, distribution (including protein binding), metabolism, or excretion of another medication (the object drug), resulting in altered concentrations of the object drug.
Drug Interactions with Fruit Juices
G6PD Deficiency and Drug Interaction
Grapefruit Drug Interaction
Drug interactions with grapefruit. Clinical significance.
Drug Interactions with Grapefruit Juice
Grapefruit juice affects how some drugs are changed in the body for eventual elimination.
HIV Drug Interactions
Interactions Between Herbs and Cardiac Medications
Interactions with Systemic Antifungals
P-glycoprotein and its role in drug-drug interactions
Herbal Medicinals – Selected Clinical Considerations Focusing on Known or Potential Drug-Herb Interactions
Review from JAMA Internal Medicine — Herbal Medicinals — Selected Clinical Considerations Focusing on Known or Potential Drug-Herb Interactions
Top 10 Particularly Dangerous Drug Interactions in Long Term Care
Drug Safety & Warnings
Australian Medicines Safety Update
Medicines Safety Update provides practical information and advice on drug safety and information about emerging safety issues.
Center for Adverse Drug Monitoring – New Zealand
Drug Eruption Global Database
We allow you to search the profiles of thousands of generic and trade name drugs, while also providing over 60,000 references that link directly to PubMed, enabling you to better diagnose and treat your patients.
European Agency for the Evaluation of Medicinal Products (EMEA)
European Union agency responsible for the protection of public and animal health through the scientific evaluation and supervision of medicines.
ISMP – Canada
ISMP Medication Safety Alert – US
The Institute for Safe Medication Practices (ISMP) is devoted entirely to medication error prevention and safe medication use. ISMP represents over 30 years of experience in helping healthcare practitioners keep patients safe, and continues to lead efforts to improve the medication use process. The organization is known and respected worldwide as the premier resource for impartial, timely, and accurate medication safety information.
Medical Errors & Patient Safety – Agency for Healthcare Research and Quality (AHRQ)
Medicines and Healthcare products Regulatory Agency
The Medicines and Healthcare products Regulatory Agency regulates medicines, medical devices and blood components for transfusion in the UK.
Monitoring the safety and quality of medicines
New Zealand Medicines and Medical Devices Safety Authority (Medsafe)
Swedish Medical Products Agency (MPA)
The Medical Products Agency (MPA) is the Swedish national authority responsible for regulation and surveillance of the development, manufacturing and sale of drugs and other medicinal products.
Uppsala Monitoring Centre – WHO
US-FDA Center for Drug Evaluation and Research (CDER)
US-FDA MedWatch – Medical Product Safety Information
WHO Drug Alerts
WHO Pharmaceuticals Newsletter
WHO Medicines Safety
Adverse Respiratory Reactions to Long-acting Beta-agonists
Alendronate and Oesophageal Ulceration
Atypical antipsychotic-induced blood dyscrasias
Atypical Antipsychotics May Cause Hypertension
Beta Blockers and Airway Disease
Carbamazepine induced Blood Dyscrasias and Skin Rash
Diarrhoea with Beta-Blockers
Drug Induced Hyponatraemia
Drug Induced Osteoporosis (DIO)
Drug-Induced QT Prolongation
Drugs & Gastrointestinal Bleeding
Guidelines for the Prevention of Contrast-Induced Nephropathy Utilizing Hydration & N-acetylcysteine
Hyperprolactinaemia With Antipsychotics
Medication induced esophagitis
Medication Induced Urine Discoloration & Urinalysis
Medications which may cause discoloration of urine (Table)
Medication-Induced Discoloration of Feces
Medications which may discolor the stool.
Medications which may induce fever (Adverse effect).
Medications which may induce hyperglycemia (increased blood sugars) (Adverse effect).
Medications which may reduce the neutrophil count (neutropenia).
platelets, thrombocytopenia, reduced platelet count, hematological side effects
Serotonin Syndrome: Recognition and Management
Serotonin syndrome is a potentially life-threatening condition caused by excessive serotonergic activity in the nervous system. It is characterized by mental status changes, autonomic instability, and neuromuscular hyperactivity.
The truth about drug fever
10 Strategies to Reduce Medication Errors
ASHP Guidelines on Preventing Medication Errors in Hospitals
Attacking the Medication Error Problem
ISMP’s List of Confused Drug Names
Guidelines for Preventing Medication Errors in Pediatrics
Learning from Medication Errors
Home PJ (Current issue) Meetings and Conferences
Medication Tools and Safety Resources
Preventing Inadvertent IV Administration of Nimodopine Capsule Contents
Success with New Year’s resolutions requires more than personal resolve
Sound alike look alike medication to be aware of list
Strategies for Preventing Medication Misadventures: Impact on Insulin Safety
The Pharmacist’s Role in a Quality System to Prevent Medication Errors
The Pharmacy Technician – A Key to Reducing Medication Errors Part 1
The Pharmacy Technician – A Key to Reducing Medication Errors Part 2
The Pharmacy Technician – A Key to Reducing Medication Errors Part 3
Wrong-Patient Medication Errors: An Analysis of Event Reports in Pennsylvania and Strategies for Prevention
Poison Control & Toxicology
Guidelines for poison control – WHO
Toxic Substances Portal
The Agency for Toxic Substances and Disease Registry (ATSDR), based in Atlanta, Georgia, is a federal public health agency of the U.S. Department of Health and Human Services. ATSDR serves the public by using the best science, taking responsive public health actions, and providing trusted health information to prevent harmful exposures and diseases related to toxic substances.
Toxicology, environmental health, and chemical databases and other information resources from the Toxicology and Environmental Health Information Program, National Library of Medicine, National Institutes of Health
AACT – American Academy of Clinical Toxicology
The American Academy of Clinical Toxicology (AACT) is a not-for-profit multi-disciplinary organization uniting scientists and clinicians in the advancement of research, education, prevention and treatment of diseases caused by chemicals, drugs and toxins.
Agency for Toxic Substances and Disease Registry (ATSDR) Tox FAQs
The ATSDR ToxFAQs is a series of summaries about hazardous substances developed by the ATSDR Division of Toxicology. Information for this series is excerpted from the ATSDR Toxicological Profiles and Public Health Statements. Each fact sheet serves as a quick and easy to understand guide.
American Association of Poison Control Centers (AAPCC)
Antidote chart California Poison Control System
Arizona Poison and Drug Information Center Home
Consumer Products Safety – Health Canada
Health Canada’s role in consumer product safety; links to health risk and safety hazard information, research, reports, advisories, recalls, safety testing, and legislation with topical content related to children’s, household, cosmetic, pest management and recreational products
Cornell University Poisonous Plants Home Page
Department of Animal Science at Cornell University; This site contains information about plants which are poisonous to or adversely affect animal health.
EXTOXNET – The Extension Toxicology Network
Infants of Drug-Abusing Mothers
Jeffrey L. Segar, MD
Know Your Plants – Poisoning
Medline Plus: Poisoning
MSDS-SEARCH – The National MSDS Repository
The First Place to Look for an MSDS, MSDSSEARCH is the most comprehensive single address for
free information related to the document known as a Material Safety Data Sheet (MSDS), providing access to over 2,500,000 MSDSs, 6000 links
directly to manufacturers, plus links to databases, software vendors, and government sources and organizations.
Side Effects and Managements
Blood and Marrow Transplant Program – Supportive Care Guidelines
Beta Blockers and Airway Disease
Preventing Allergic Reactions to Drugs
DefinitionDrug allergies are a group of symptoms caused by an allergic reaction to a drug (medication).Alternative NamesAllergic reaction – drug (medication); Drug hypersensitivity; Medication hypersensitivityCausesAdverse reactions to drugs are common. (adverse means unwanted or unexpected.) Almost any drug can cause an adverse reaction. Reactions range from irritating or mild side effects such as nausea and vomiting to life-threatening anaphylaxis.
Preventing Nosebleeds from Nasal Steroids
Viagra Side Effects (Sildenafil)
Learn about the potential side effects of Viagra (sildenafil). Includes common and rare side effects information for consumers and healthcare professionals.
Cancer Side Effects and Their Management
Cancer and cancer treatment often cause a variety of side effects. Talk with your doctor about which side effects are likely based on your specific treatment plan. An important part of cancer care is relieving side effects, called symptom management, palliative care, or supportive care. It is important to talk with your health care team about the specific side effects you experience and the best ways to manage and treat them.